Immunological infertility disease affects both men and women, causing their immune systems to strive against of sperm. The main cause of the development of the immunological infertility is antisperm antibodies in the person’s body. However, doctors identify a few more reasons for the development of this disease.

Causes of immunological infertility among women:

  • Family autoimmune diseases (lupus erythematosis, hypothyroidism, rheumatoid arthritis, etc.);
  • Surgical measure;
  • Endometriosis;
  • Recurrent IVF failures;
  • Unexplained infertility;
  • Recurrent miscarriages;
  • Sexually-transmitted infections;
  • Chronical inflammatory disease;
  • Woman’s organism produce antibodies reacting on her baby’s DNA or DNA breakdown product;
  • Hyperactive natural killer cells can damage the cells which produce the placenta and the endocrine system that create needed hormones for successful pregnancy;
  • In rare cases woman can have an allergic reaction to her partner’s sperm. It stimulates her immune system to create antisperm antibodies (ASA) that will attack her partner’s sperm.

All these causes lead to the fact that woman’s immune system begins to take sperm cell as “strangers” and minimize chances to get pregnant.



Causes of immunological infertility among men:

Man’s organism can create antisperm antibodies when the sperm come into contact with his natural killer cells of immune system. The ASA identify the semen and the sperm as the “enemy”. It can occur for the following reasons:

  • Anatomical disruption (groin hernia, varicocele, inverted testis, cryptorchidism etc.);
  • Sexually-transmitted infections;
  • Oncological diseases;
  • Traumas and operations on the pelvic organs;
  • Chronical inflammatory diseases (prostatitis, epididymitis, orchitis);

More than 70% of all men who get a vasectomy will produce antisperm antibodies.