Immunological infertility and gynecological diseases

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This topic contains 11 replies, has 12 voices, and was last updated by Meredit Meredit 2 years, 8 months ago.

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  • #202
    Tina
    Tina
    Participant

    To the development of infertility may result in the development of diseases in the uterus, tubes, ovaries and even the vagina and the vulva: a complication of infectious, neoplastic degeneration, degenerative disorders, and the effects of mechanical (repeated curettage of the uterus) effects.
    In the normal functioning of all cellular elements of the endometrium after fertilization, the structure of the endometrium is optimal for implantation and development of the ovum.
    To the development of infertility are often caused by endometriosis of different localization (uterus, epididymis, tubes, abdominal cavity). These women in the study of blood were found antiendomysial antibody that plays an important role in the development of infertility and higher rate of spontaneous miscarriages.
    Important role in the development of infertility is the presence of uterine fibroids, or surgical removal of fibroids in women. Infertility in this case is explained by violation of the endocrine processes in all of women’s reproductive systems.
    You need to consider the presence in a woman’s body ovulation stimulation with clomiphene, which may also be a cause of infertility (affects the implantation of the ovum through an antiestrogenic effect on the endometrium receptors, but this mechanism has not been studied enough).

    #247
    Jessica
    Jessica
    Participant

    An increasing body of evidence suggests that immune-mediated processes affect female reproductive success at multiple levels. Crosstalk between endocrine and immune systems regulates a large number of biological processes that affect target tissues, and this crosstalk involves gene expression, cytokine and/or lymphokine release and hormone action. In addition, endocrine–immune interactions have a major role in the implantation process of the fetal (paternally derived) semi-allograft, which requires a reprogramming process of the maternal immune system from rejection to temporary tolerance for the length of gestation. Usually, the female immune system is supportive of all of these processes and, therefore, facilitates reproductive success. Abnormalities of the female immune system, including autoimmunity, potentially interfere at multiple levels. The relevance of the immune system to female infertility is increasingly recognized by investigators, but clinically is often not adequately considered and is, therefore, underestimated. This Review summarizes the effect of individual autoimmune endocrine diseases on female fertility, and points towards selected developments expected in the near future.

    #287
    Brook
    Brook
    Participant

    Estrogen-dependent gynecological disease, such as breast and endometrial cancer and endometriosis, rarely arise in women who have been castrated at an early age and who have not received hormone replacement. Patients status post oophorectomy who develop these disorders many years later may harbor gain-of-function mutations resulting in overproduction of estrogen. We plan to identify patients who have developed severe estrogen-dependent disorders despite presumed estrogen deficiency to order to screen for mutations. These “experiments of nature” may enable us to identify genes already implicated in disorders of estrogen excess (e.g. aromatase, estrogen receptor alpha), identify new genes involved in these disorders, and establish genotype-phenotype correlations for the genetic defects discovered.

    #360
    Caroline
    Caroline
    Participant

    Several lines of evidence suggest that autoimmune mechanisms may influence the reproductive life and fertility of both sexes, commonly manifesting as infertility or pregnancy loss. Part of the controversy that characterizes this assumption derives from the overlooked suspect of autoimmune conditions in the absence of symptoms or the limited physician awareness in a gynecological setting. Numerous autoimmune diseases, including but not limited to systemic lupus erythematosus and anti-phospholipid syndrome, may be associated with infertility and pregnancy loss through different putative mechanisms. First, serum autoantibodies such as anti-phospholipid, anti-thyroid, or antinuclear antibodies may be directly associated with infertility, regardless of the presence of a clinically overt autoimmune disease. Second, autoimmunity may affect all stages of fertility, via ovarian failure, testicular failure, implantation failure, and pregnancy loss. Third, infertility may also be secondary to vasculitis associated with other conditions such as systemic lupus erythematosus and diabetes mellitus. This review article will illustrate and critically discuss the available data on the link between the breakdown of tolerance that characterizes autoimmune diseases and the changes in reproductive life that affect patients in real clinical setting and that often constitute the iatrotropic stimulus.

    #412
    Ornella
    Ornella
    Participant

    I know that there many gynecological deseases that can lead to infertility. Doctors say that there are three the most dangerous illnesses:
    1.Pelvic inflammatory disease: it is the most common yet serious complication – outside of the HIV virus (cause of AIDS) – of sexually transmitted diseases.
    2.Chlamydia: Chlamydia is the most commonly reported STD in the U.S. Left untreated, 40 percent of women develop PID and 20 percent of these become infertile. 75 percent of women with chlamydia experience no symptoms and may not seek treatment.
    3.Endometriosis: It is estimated that between 2 and 10 percent of women (5.5 million of childbearing age) have endometriosis.
    Also we should not forget about cancer, especially Breast cancer, Endometrial cancer, Ovarian cancer, Cervical cancer, Vulva cancer and Vaginal cancer which are potentially causes of female infertility.

    #471
    Allie
    Allie
    Participant

    In the uterus due to hormone imbalance occurs excessive growth of the mucous membrane that has been called hyperplasia. This pathological condition may show local changes in the mucous, then it is considered to be endometrial polyps. The question of what is the pathology of the endometrium, should be read in conjunction with specialists from related professions (doctors pathologists, histology). Confirm the presence of the pathological nature of the changes can only be carried out on the basis of histological examination.
    Quite often, endometrial pathology combined with diseases of the reproductive system: endometriosis,hysteromyoma…

    #538
    Sonia
    Sonia
    Participant

    If the female body in addition to the formation of sex cells fertilization, bearing and full development of the unborn child, the male, only sperm are formed. To fertilization has occurred with high probability, the sperm must be many and they must be sufficiently mobile.
    Lack of protein in food, vitamin deficiency, testicular injury, occupational hazards – factors that often cause disturbances of spermatogenesis, but they are very easy to eliminate.
    Varicocele – varicose veins of the spermatic cord. In the evolution of the male sex gland descended into the scrotum for the reason that for the formation of healthy sperm need a temperature lower than the body. If the veins dilate due to the larger amount of blood temperature is rising and disrupted spermatogenesis.

    #571

    Kara
    Participant

    Health problems that cause hormonal changes. There are some health problems, which can also increase the risk of infertility. Women who suffer from irregular menstruation or absence of menstruation, painful menstruation, polycystic ovary syndrome (PCOS), endometriosis, pelvic inflammatory disease, uterine fibroids, or more than one miscarriage should consult your gynecologist or obstetrician.
    Hypothyroidism. Many women who are diagnosed with hypothyroidism, it is very difficult to get pregnant due to irregular menstruation and lack of ovulation.
    Hyperthyroidism. Just as in hypothyroidism, lack of egg release in hyperthyroidism may make it impossible for a woman to become pregnant.

    #605
    Margo
    Margo
    Participant

    cervical disease. The cervix – is the body through which is embryo transfer during IVF and that affects the safe carrying of pregnancy. Therefore prior to treatment of infertility cervical inspection and, if necessary, treatment of identified pathology is mandatory. Sometimes, when there is an active HPV infection, treatment can be quite time-consuming and tedious, but it should go through. Any comorbidities should be identified prior to IVF. In this preliminary survey directed everything. Diseases of the kidney, liver, thyroid, breast, and other organs should be installed and possibly treated prior to IVF.

    #607
    Nina
    Nina
    Participant

    For successful IVF it is very important to the absence of inflammation in the mucous membrane of the cervix and, therefore, swabs are taken before each IVF procedure and achieve normal content of white blood cells – the indicator of inflammatory activity. Swabs taken from the vagina is menstruation, the cervix and sometimes the urethra.A few words should be said about the anti-inflammatory treatment.As a rule, tubo-peritoneal infertility is a consequence of chronic inflammation in the pelvis, resulting from the banal or specific (gonorrhea, tuberculosis) infection, often as a complication of abortion.

    #672

    Sarah
    Participant

    you know i can say that this pathological condition may show local changes in the mucous, then it is considered to be endometrial polyps.
    The question of what is the pathology of the endometrium, should be read in conjunction with specialists from related professions , doctors pathologists, histology.
    Confirm the presence of the pathological nature of the changes can only be carried out on the basis of histological examination.

    #707
    Meredit
    Meredit
    Participant

    I think that this pathological condition may show local changes in the mucous, then it is considered to be endometrial polyps.
    The question of what is the pathology of the endometrium, should be read in conjunction with specialists from related professions (doctors pathologists, histology). Confirm the presence of the pathological nature of the changes can only be carried out on the basis of histological examination.
    Quite often, endometrial pathology combined with diseases of the reproductive system: endometriosis,hysteromyoma…

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